Can gout be inherited? Will it affect the next generation

1、 Can gout be inherited

Primary gout can be inherited.

Gout is a congenital metabolic genetic defect, which has been confirmed by clinical practice. About 10% – 25% of gout patients have a family history, and 10% of their close relatives have a family history

~25% had hyperuricemia; generally, if one of the parents had gout, 15% ~ 30% of the children would have gout; if both parents had gout, 55% of the children would have gout. Therefore, it is believed that primary gout can be inherited.

Although gout has the possibility of familial high incidence, this does not mean that the father has gout, the son will certainly have gout. Gout patients have the right to procreation and do not affect the normal life of husband and wife. However, in the first-degree kinship, if there are two gout cases in the family, the gout prevalence rate of offspring in this family will be significantly increased, and regular examination is required.

Can gout be inherited? Will it affect the next generation

2、 Genetic mechanism of gout

The essence of gout genetic defect, like other genetic diseases, is mainly gene mutation. Genes exist on the chromosomes of human cells. They carry the genetic code and control the synthesis of proteins and enzymes, thus affecting the metabolism of uric acid. Gout is due to the mutation of some enzyme genes that control the production of uric acid, resulting in an increase of uric acid production. However, the specific genetic model is not clear, and there is a lack of reliable and sensitive genetic markers. At present, in addition to a small amount of purine metabolic enzyme deficiency caused by gout has been confirmed to be linked to recessive inheritance and familial juvenile hyperuricemia nephropathy is autosomal recessive inheritance, the genetic model of most primary gout is still uncertain.

Can gout be inherited? Will it affect the next generation

3、 How to prevent gout

1. The blood uric acid of gout patients should be rapidly reduced to normal, and the long-term and uninterrupted use of anti uric acid drugs should be insisted on. Allopurinol, a xanthine inhibitor that inhibits the synthesis of uric acid, is the first choice.

2. Active treatment of gout associated diseases and complications. Gout is often associated with obesity, hypertension, diabetes, lipid metabolism disorder, fatty liver, etc.; it is often associated with kidney stones, renal insufficiency, cardiovascular and cerebrovascular diseases.

3. For the offspring and close relatives who have not suffered from the disease, we should often test the blood uric acid and carry out relevant examinations. Generally, it is better to test once every 3-6 months.

4. No matter whether they are ill or not, they should be actively prevented. From childhood, we should develop good living habits, strictly limit purine-rich food, drink less, do not eat animal viscera, the proportion of protein in the diet should not be too high, properly control the amount of food, and strictly control the weight according to the body mass index standard.

5. If the blood uric acid is found to be elevated in the offspring and close relatives, the anti uric acid drugs should be used immediately, and allopurinol is also the first choice.

6. Balanced nutrition, diet principle is high carbohydrate, medium amount of protein, and low fat. Specifically speaking, carbohydrates such as rice and noodles should account for

55% ~ 60% of the total calories can reduce the production of ketone body by fat decomposition, which is conducive to the excretion of urate; protein should account for 11% ~ 15% of the total calories, and the daily intake is usually 0.8 ~ 1.0 g / kg body weight; the rest of the calories are distributed to fat, usually 40 ~ 50 g / day.